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Endocrine and metabolic: False positive readings for glucose urine tests may occur with Clinitest(R), Benedict Solution, or Fehling Solution; enzymatic glucose oxidase reaction-type tests recommended.
Gastrointestinal: Clostridium difficile-associated diarrhea, including mild diarrhea to fatal colitis, has been reported and may occur over 2 months from last dose; discontinuation of antibiotics not directed against C. difficile may be required if suspected or confirmed.
Immunologic: Severe anaphylactic reactions, including fatalities, have been reported, especially in patients with a history of penicillin hypersensitivity or sensitivity to multiple allergens; discontinue if allergic reaction occurs.
Mononucleosis: Avoid use due to a high risk of developing an erythematous skin rash.
Renal: Severe renal impairment (ie, GFR less than 30 mL/min) or hemodialysis; dose adjustment is recommended.
